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These beneficial effects on airway inflammation and tone have also been noted after administration of N -acetylcysteine amide and N -acetyl cysteine proline cysteine amide, which have increased membrane permeability and greater reducing activity than N -acetylcysteine (168, 183)

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In addition, there is a splice variant PAPSS2b which contains an extra five amino acid sequence GMALP [13,14]